Purine derivatives and their use as anti-coagulants

Details Purine derivatives and their use as anti-coagulants Purine derivatives and their use as anti-coagulants

1996-08-16

1998-05-19

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514261, 514262, 514263, 514265, 514266, 544244, 544268, 544270, 544271, 544272, 544277, 544311, 544313, C07D47330, C07D47304, C07D47316, C07D47322

Patent

active

057536350

ABSTRACT:
This invention is directed to purine derivatives of the following formulae: ##STR1## wherein Z.sup.1 is --O--, --N(R.sup.10)-- or --CH.sub.2 O--;

REFERENCES:
patent: 5332822 (1994-07-01), Misra
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombis Research, (1980) 19:339-349.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine--Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by (2R, inyl)-2piperidinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinase XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545-548.

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