Treatment for inhibiting the progression of autoimmune disease

Details Treatment for inhibiting the progression of autoimmune disease Treatment for inhibiting the progression of autoimmune disease

1995-05-12

1998-05-19

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, 514 16, 514 17, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

057536252

ABSTRACT:
The progression of autoimmune disease is inhibited by the administration of peptides having the sequence of MHC Class I antigen .alpha.1-domains. These fragments include the amino acids between positions 70 and 91 of the MHC Class I antigens. The onset of IDDM is significantly decreased by the subject treatment.

REFERENCES:
Nisco et al., Journal of Immunology, 1994, pp. 3786-3792, vol. 152.
Stagsted et al., Cell, vol. 62, pp. 297-307.
Cuturi et al., Prolongation of Allogeneic Heart Graft Survival in Rats by Administration of a Peptide (a.a. 75-84) From the .alpha.1 Helix of the First Domain of HLA-B7 01 (1995) Transplantation, vol. 59, No. 5:661-669.
Buelow et al., Immunomodulation by Soluble HLA Class I (1995) Transplantation, vol. 59, No. 5:649-654.
Buelow et al., Prolongation of Skin Allograft Survival in Mice Following Administration of Allotrap.sup.1 (1995) Tranplantation, vol. 59, No. 4:455-460.
Stagsted et al., Regulation of Insulin Receptor Functions by a Peptide Derived from a Major Histocompatibility Complex Class I Antigen (1990) Cell, vol. 62:297-307.
Nisco et al., Induction of Allograft Tolerance in Rats by an HLA Class-I-Derived Peptide and Cyclosporine A.sup.1 (1994) J. of Immunology.
Kabat et al., (1991) Sequences of Proteins of Immunological Interest, NIH publication No. 91-3242, vol. 1:738-740, 761, 770-771, 779-780, 788-789 and 802-804.

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