Production of uridine

Details Production of uridine Production of uridine

1985-10-18

1989-11-14

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435832, 435836, 435839, C12P 1938, C12R 107

Patent

active

048807362

ABSTRACT:
Uridine is produced by cultivating in a culture medium a uridine-producing microorganism, which belongs to the genus Bacillus and which is deficient in uridine nucleoside phosphorylase activity and is resistant to a pyrimidine analogue, and recovering the accumulated uridine. This method has the advantage of substantially avoiding the by-production of uracil and uridylic acid.

REFERENCES:
patent: 3139385 (1964-06-01), Ogata et al.
Sakai, T., Tochikura T., and K. Ogata, 1966, Metabolisms of Nucleosides in Bacteria, Apr. Biol. Chem. 30(3), 245-253.
Imada A., and S. Igarasi 1967, Ribosyl and Deoxypribosyl Transfer by Bacterial Enzyme Systems, J. Bacteriol 94(5), 1551-1559.
Jensen K. F., Neuhard J. and L. Schack 1982, RNA Polymerase Involvement in the Regulation of Expression of Salmonella Typhimerrium pyr Genes, Isolation and Characterization of a Fluorouracil--Resistive Mutant with High Constitutive Expression of the pyr B and pyr E Genes Due to a Mutation in rpo BC, EMBO Journal 1(1), 69-74.
Saunders, P. P., Wilson B. A., and G. F. Saunders, 1969, Purification and Comparative Properties of a Pyrimidine Nucleoside Phosphroylose from Bacillus Stearothermophilus. J Bio. Chem. 244: 3691-3697.
O'Donovan G. A., and J. C. Gerhart 1972, Isolation and Partial Characterization of Regulatory, Mutants of the Pyrimidine Pathway in Salmonella Typhimurium, J. Bacteriol 109(3), 1085-1096.
Central Patents Index, Abstracts Journal, Section D, No. 02966A/02, the Abstract of Japanese Patent Publication (laid open) No. 52--139786.
Central Patents Index, Abstracts Journal, Section D, No. 35985A/20, the Abstract of Japanese Patent Publication (laid open) No. 53--38691.

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