Polypeptides involved in the biosynthesis of streptogramins, nuc

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 41, 43525233, 4353201, 536 231, 536 232, 536 237, 530350, C12N 900, C12N 120, C07H 2104

Patent

active

060776994

ABSTRACT:
Disclosed is the nucleic acid sequences for polypeptides and enzymes involved in the biosynthesis of streptogramins from Streptomyces sp. and the corresponding amino acid sequences. Also disclosed are recombinant vectors and cells as well as methods of making the polypeptides, enzymes and streptogramins using the recombinant host cells.

REFERENCES:
patent: 5252474 (1993-10-01), Gewain et al.
patent: 5591614 (1997-01-01), Blanche et al.
Biot et al., Virginiamycin: Properties, Biosynthesis, and Fermentation Drugs and the Pharmaceutical Sciences 22:695-720 (1984).
Blumauerova et al., "Physiological and Genetic Aspects of Vriginiamycin Production," Folia Microbiologica, Prague 35(6)494 (1990).
Chater et al., "The improving prospects for yield increase by genetic engineering in antibiotic-producing streptomycetes," Biotechnology 8:115-121 (1990).
Kazumi et al., "Isolation and properties of IM factor (an inducer of secondary metabolite production) deficient mutants of Streptomyces virgineae MAFF 10-06014," Chemical Abstracts 115(23) :251978n (1991).
Hallam et al., "Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antiobiotic synthesis in Streptomyces coelicolor," Gene 74:305-320 (1988).
Paquet et al., "Induction of Pristinamycins Production in Streptomyces pristinaespiralis," Biotechnology Letters 14 (11) :1065-1070 (1992).
Prikrylova et al., "Strain Development in Streptomyces virginiae, a Producer of Virginiamycyn," Biotechnology and Bioindustry 2:20-22 (1988).
Francis et al. "Biosynthesis of chloramphenicol in Streptomyces species 3022a: the nature of arylamine synthase system" Can J. Microbiol. 25, 1408-1415, 1979.
Spyrou et al. "Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme" J. Bacteriol. 173, 3673-3679, Jun. 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polypeptides involved in the biosynthesis of streptogramins, nuc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides involved in the biosynthesis of streptogramins, nuc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides involved in the biosynthesis of streptogramins, nuc will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1851040

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.