Diagnosis of motor neuropathy by detection of antibodies

Details Diagnosis of motor neuropathy by detection of antibodies Diagnosis of motor neuropathy by detection of antibodies

1997-06-30

2000-06-20

Duffy, Patricia A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 795, 435967, 435975, 436518, 436524, 436528, 436532, 436 71, 436811, G01N 3353

Patent

active

060776811

ABSTRACT:
Methods of detecting antibody to GM1 ganglioside in a sample, comprising covalent linkage of GM1 ganglioside to a solid-phase reactant, are disclosed. The methods of detecting antibody to GM1 ganglioside can be used in methods of diagnosing motor neuropathies, such as multifocal motor neuropathy or immune-mediated motor neuropathy, in an individual. The amount of antibody specific to GM1 ganglioside in a test sample from a individual is measured; a titer of antibody to GM1 ganglioside that is greater than 1,800 is indicative of disease.

REFERENCES:
Harlow et al, Antibodies a Laboratory Manual., Cold Spring Harbor Laboratory, 1988 pg. vi.
Roses et al eds, Manual of Clinical Laboratory Immunology, Third Edition, American Society for Microbiology, Washington D.C., 1986. pg. 88-98 and 101-102.
Taki et al. J. Biochem. 107: 493-498, 1990.
van Schalk et al., Neurology, 45: 1570-1577, 1995.
Ravindranath et al, Journal of Immunological Methods, 169:257-272, 1994.
Younes--Chennoufi et al., Neurochem. Int, 20(3):353-357, 1992.

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