Single-chain polypeptides comprising troponin I and troponin C

Details Single-chain polypeptides comprising troponin I and troponin C Single-chain polypeptides comprising troponin I and troponin C

1997-12-18

2000-06-20

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 691, 4352523, 43525233, 4353201, 530350, 436 234, C12N 1562, C07K 1447, G01N 3368

Patent

active

060776765

ABSTRACT:
This invention relates to single-chain polypeptides and their genetic sequences comprising human cardiac troponin I and troponin C. The single-chain polypeptide may be expressed recombinantly, and a linker peptide may be interposed between the troponin sequences. A linker peptide of about 6 to about 30 amino acids is preferred. The single-chain polypeptide has utility as a control or calibrator for troponin assays, for the purification of troponin subunits and as an antigen for the preparation of antibodies.

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