Target antigens of transmission blocking antibodies for malaria

Details Target antigens of transmission blocking antibodies for malaria Target antigens of transmission blocking antibodies for malaria

1995-05-30

1998-05-19

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

4242681, 4241841, 4241851, 435 691, 435 693, 435252, 530350, A61K 39015, C12N 1563, C12N 1583, C12N 1587

Patent

active

057532389

ABSTRACT:
The present invention relates novel methods and compositions for blocking transmission of Plasmodium spp. which cause malaria. In particular, P28 proteins are disclosed which, when administered to a susceptible organism, induce an immune response against a 28 kD protein on the surface of Plasmodium ookinetes and block transmission of malaria.

REFERENCES:
Wizel et al PNAS 88:9533-9537, 1991.
Kaslow Vaccine Research 2:197-205, 1993 Toward a Transmission-Blocking Vaccine for Malaria.
Williamson et al Anal Biochem 206:359-362, 1992.
Grotendorst et al Infection & Immunity 45:775-777 1984.
Venmeulen et al J. Exp. Medicine 162:1460-1476 1985.
Kaslow Immunology Letters 25:83-86, 1990.
Cox TIBTECH 9:389-394, 1991 Malaria Vaccines--Progress and Problems.

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