Dopaminergically stimulating 4-substituted indoles

Details Dopaminergically stimulating 4-substituted indoles Dopaminergically stimulating 4-substituted indoles

1980-12-31

1982-06-01

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424267, 546201, 546273, 548469, A61K 3144, A61K 31445, C07D40102

Patent

active

043328083

ABSTRACT:
Novel indoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 12 carbon atoms, X is selected from the group consisting of hydrogen and alkyl of 1 to 18 carbon atoms, Y is selected from the group consisting of hydrogen and halogen, Z is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, hydroxy alkyl of 1 to 8 carbon atoms, aryloxyalkyl of 7 to 12 carbon atoms, arylalkyl of 7 to 12 carbon atoms optionally substituted with at least one member of the group consisting of halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, --OH, --CF.sub.3, --OCF.sub.3, --NO.sub.2 and NH.sub.2, cycloalkylalkyl of 4 to 12 carbon atoms, alkenyl of 3 to 8 carbon atoms and alkynyl of 3 to 8 carbon atoms, and a and b may each be hydrogen or form a double bond or a is hydrogen and b is selected from the group consisting of --OH and alkoxy of 1 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic stimulating properties optionally accompanied with adrenergic and serotoninergic activity and their preparation and novel intermediates.

REFERENCES:
patent: 3510491 (1970-05-01), Bell
Chemical Abstracts, 61:16036g (1964) [Bull. Soc. Chim. France 1964(8), 1939-1945, Marc, J., et al.].
Chemical Abstracts, 68:49392x (1968) [C. R. Acad. Sci., Paris, Ser. C 265(2), 110-112 (1967), Marc, J., et al.].

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