Preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyla

Details Preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyla Preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyla

1980-10-02

1982-06-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

26032614R, 564251, C07D20928

Patent

active

043327273

ABSTRACT:
The invention relates to a process for the production of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetoxyacetic acid (known to be useful as an antiphlogistic agent) which comprises reacting .alpha.-(4-chlorobenzoyl)-4-methoxyphenylhydrazine hydrochloride or sulphonate with laevulinoyloxyacetic acid and cyclizing the resulting hydrazone to obtain a product free from 1-benzoyl-5-methoxy-2-methyl-3-indolylacetoxyacetic acid.

REFERENCES:
patent: 3910952 (1975-10-01), Boltze et al.
patent: 3962471 (1976-06-01), Bieve et al.
Rodd, Chem. of Carbon Cmpds., vol. IV, part A, pp. 71-73, Elsevier, N.Y., N.Y., (1957).

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