Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe

Details Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe

1980-03-04

1982-06-01

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

549253, C07C10352, C07D30760

Patent

active

043327184

ABSTRACT:
A process for producing an .alpha.-L-aspartyl-L-phenylalanine lower alkyl ester or its hydrochloride which comprises (a) treating an L-N-(1-methyl-2-lower aliphatic acylvinyl or 1-methyl-2-lower alkoxycarbonylvinyl)-aspartic acid or an alkali metal salt thereof with a dehydrating agent in an organic solvent containing an acid, (b) reacting the solution resulting from such treatment with an L-phenylalanine lower alkyl ester and (c) treating the resulting reaction mixture with water or an aqueous acid solution to remove the 1-methyl-2-lower aliphatic acylvinyl or 1-methyl-2-lower alkoxycarbonylvinyl group from the L-N-(1-methyl-2-lower aliphatic acylvinyl or 1-methyl-2-lower alkoxycarbonylvinyl)-aspartyl-L-phenylalanine lower alkyl ester is disclosed, along with L-N-(1-methyl-2-acetylvinyl)-aspartic acid anhydride.

REFERENCES:
patent: B485972 (1976-03-01), Farkas et al.
patent: 3462460 (1969-08-01), Kollonitsch
patent: 3808190 (1974-04-01), Dahlmans et al.
patent: 3872110 (1975-03-01), Ariyoshi et al.
patent: 3901871 (1975-08-01), Anderson
patent: 3933781 (1976-01-01), Bachman et al.
patent: 3948971 (1976-04-01), Veber et al.
patent: 3962207 (1976-06-01), Uchiyama et al.
patent: 4017472 (1977-04-01), Farkas et al.
Derwitt abstr. of Japanese Pat. No. J5-5035-059, Sep. 5, 1978.
Chem. Abstr., vol. 78, (1973), 111764g, 98023e.
Chem. Abstr., vol. 80, (1974), 27474w.
Chem. Abstr., vol. 79, (1973), 66803b.
Chem. Abstr., vol. 84, (1976), 31506h.
Chem. Abstr., vol. 85, (1976), 6056x.

Affiliated with

Also associated with

Rating

Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing an .alpha.-L-aspartyl-L-phenylalanine lowe will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1848818