Ascorbate interference-resistant composition, device and method

Details Ascorbate interference-resistant composition, device and method Ascorbate interference-resistant composition, device and method

1991-05-13

1993-11-23

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 4, 435 10, 435 11, 435 14, 435 25, 436 66, 436 73, 436 74, 436800, 436904, C12Q 128, G01N 3320

Patent

active

052643484

ABSTRACT:
A new and improved test device and method of determining the presence or concentration of a predetermined analyte, such as glucose, cholesterol or occult blood, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with the predetermined analyte to produce a detectable or measurable response. In addition, the new and improved indicator reagent composition, comprising an indicator dye, such as a redox indicator, like a benzidine indicator; a redox mediator, such as an oxidase enzyme capable of interacting with the predetermined analyte and a peroxidase enzyme; a metal ion complex; and a cooxidant selected from the group consisting of bromate ion, chlorate ion, perchlorate ion, chromate ion, an organic oxidant like a peroxide, a hydroperoxide or a N-halo compound, and combinations thereof, is incorporated into the carrier matrix to provide a more accurate, ascorbate interference-resistant assay of a test sample for the predetermined analyte.

REFERENCES:
patent: 5079140 (1992-01-01), Albarella et al.
Birk, Inorg. Chem., vol. 12, pp. 2468-2472, 1973.
Birk et al., Inorg. Chem., vol. 17, pp. 1186-1191, 1978.
Kozub, Ph.D. Dissertation, Xerox University Microfilms, Ann Arbor, 1975.

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