DNA encoding cytokine-induced protein, TSG-14

Details DNA encoding cytokine-induced protein, TSG-14 DNA encoding cytokine-induced protein, TSG-14

1992-08-14

1995-06-20

Draper, Garnette D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 4352523, 4353201, 435 691, C07H 1700, C12N 120, C12N 1500, C12P 2106

Patent

active

054261813

ABSTRACT:
Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a polypeptide molecule, termed TSG-14, in connective tissue cells. The TSG-14 polypeptide and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the polypeptide and the DNA are provided. Antibodies specific for the TSG-14 polypeptide are disclosed, as is a method for detecting the presence of TSG-14 polypeptide in a biological sample, using the antibody or another molecule capable of binding to TSG-14 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-14 polypeptide, a method for measuring induction of expression of TSG-14 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-14 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.

REFERENCES:
Lee et al, Mol. Cell Biol 10(5) 1990, pp. 1982-1988.
Lee et al J. Interferon Res 9(Suppl 2) 1989, p. 5145.
Breviario et al JBC 267(31) 1992, pp. 22190-22197.

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