Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1991-03-28
1995-06-20
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 530839, C07K 1300
Patent
active
054261775
ABSTRACT:
The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for studying the physiologic role of CNTF; (ii) diagnostic techniques for identifying CNTF-related neurologic conditions; (iv) therapeutic techniques for the treatment of CNTF-related neurologic and muscular conditions, and (v) methods for identifying molecules homologous to CNTF and CNTFR.
REFERENCES:
Seed et al. Molecular cloning of the CD2 . . . 1987. PNAS. USA. 84:3365-3369.
Lin et al. Purification, cloning, and expression . . . 1989. Science 246:1023-1025.
Munro et al. An Hsp70-like Protein in the . . . 1986. Cell 46:291-300.
Davis Samuel
Furth Mark E.
Squinto Stephen P.
Yancopoulos George D.
Hill Jr. Robert J.
Regeneron Pharmaceuticals Inc.
Teng Sally P.
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