Pyrimidinyl-glutamic acid derivatives

Details Pyrimidinyl-glutamic acid derivatives Pyrimidinyl-glutamic acid derivatives

1993-10-06

1995-06-20

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514272, 544320, 544321, 544324, 544325, 544331, 544332, A61K 31505, C07D23942, C07D23948, C07D40112

Patent

active

054261104

ABSTRACT:
The present invention provides novel pyrimidinyl-glutamic acid derivatives and intermediates thereto. Further provided are methods for inhibiting dihydrofolate reductase in mammals and for treating susceptible neoplasms in mammals, particularly humans.

REFERENCES:
patent: 4684653 (1987-08-01), Taylor et al.
patent: 4871743 (1989-10-01), Taylor et al.
patent: 4920125 (1990-04-01), Taylor et al.
Weinstock, et al., J. Med. Chem. 11(6):1238-1241 (1968).
Stuart, et al., J. Med. Chem., 26:667-673 (1983).
Taylor, et al., Heterocycles, 28(2):1169-1178 (1989).
Taylor et al., Chemical Abstracts, vol. 117, entry 212902e (1992).
Taylor et al., Chemical Abstracts, vol. 116, entry 152317k (1992).
Akimoto et al, Chemical Abstracts, vol. 115, entry 29364a (1990).

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