Phenylnaphthalene hydroxy acids

Details Phenylnaphthalene hydroxy acids Phenylnaphthalene hydroxy acids

1992-08-27

1995-06-20

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142222, 5142288, 514241, 514247, 514277, 514345, 514359, 514365, 514372, 514374, 514378, 514383, 514385, 514403, 514408, 514424, 514430, 514431, 514432, 514438, 514449, 514450, 514451, 514461, 544180, 544224, 546268, 546283, 546284, 546301, 546342, 548125, 548146, 548206, 548215, 548240, 548255, 5482622, 5483001, 5483561, 548517, 548541, 549 1, 549 13, 549 29, 549 88, A61K 3119, A61K 3133, A61K 31335, A61K 3138, A61K 31395, A61K 3144, C07D40504

Patent

active

054261090

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4486445 (1984-12-01), Patel et al.
patent: 4937373 (1990-06-01), Carson et al.
The Merck Index, 11th ed., 5154, pp. 829 (1989).

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