Conformationally restricted angiotensin II antagonists

Details Conformationally restricted angiotensin II antagonists Conformationally restricted angiotensin II antagonists

1993-09-24

1995-06-20

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514299, 514300, 514303, 514322, 514323, 514381, 540578, 540579, 540593, 546112, 546119, 546120, 546121, 546199, 546201, 548252, 548253, 548254, A61K 31435, C07D48704

Patent

active

054261058

ABSTRACT:
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest are of Formula I ##STR1## wherein W is N or CH.sub.2 ; wherein X is N or CR.sup.2 ; wherein Y is (CH.sub.2).sub.n and n is 1 to 3; wherein Z is C.dbd.R.sup.3 or CR.sup.4 R.sup.5, or wherein Y and Z together forms --CR.sup.6 .dbd.CR.sup.7 --, --CR.sup.6 .dbd.CR.sup.7 --CH.sub.2 or --CR.sup.6 .dbd.CR.sup.7 --CH.sub.2 --CH.sup.2 --; wherein the remainder of the variables are as defined in the specification; or a pharmaceutically suitable salt or tautomer thereof.

REFERENCES:
patent: 5270322 (1993-12-01), Ries et al.

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