Benzothiazine dioxide derivatives

Details Benzothiazine dioxide derivatives Benzothiazine dioxide derivatives

1981-01-15

1982-01-05

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 49, C07D27902, A61K 3154

Patent

active

043094279

ABSTRACT:
Certain novel derivatives of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared, including N-(2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-(n-butyryloxy)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, N-(6-methyl-2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxami de 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-benzoyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, N-(6-methyl-2-pyridyl)-2-methyl-4-benzoyloxy-2H-1,2-benzothiazine-3-carbox amide 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-carboxa mide 1,1-dioxide and N-(6-methyl-2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine- 3-carboxamide 1,1-dioxide. All these compounds are useful in therapy as non-steroidal anti-inflammatory agents, especially when administered by the topical route of administration. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino
patent: 3925371 (1975-11-01), Rasmussen
patent: 4116964 (1978-09-01), Zinnes et al.
J. G. Lombardino et al., "Potent Antiinflammatory N-Heterocyclic3-Carboxamides of 4-Hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide", Journal of Medicinal Chemistry, vol. 16, No. 5, p. 493, (1973).

Affiliated with

Also associated with

Rating

Benzothiazine dioxide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzothiazine dioxide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzothiazine dioxide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1844199