Process for the preparation of 1-carbapenems and intermediates v

Details Process for the preparation of 1-carbapenems and intermediates v Process for the preparation of 1-carbapenems and intermediates v

1980-03-27

1982-01-05

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602452T, C07D20508, C07D48704

Patent

active

043093469

ABSTRACT:
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via intermediates II and III: ##STR1## wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R.sup.6 and R.sup.7 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R.sup.1' is hydrogen or a protecting group; and R.sup.a, R.sup.b and R.sup.c are independently selected from alkyl, aryl and aralkyl.

REFERENCES:
patent: 4122262 (1978-10-01), Buckley et al.

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