Process for the manufacture of ceohem enol derivatives

Details Process for the manufacture of ceohem enol derivatives Process for the manufacture of ceohem enol derivatives

1979-05-07

1982-03-09

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 22, 260239A, C07D50104

Patent

active

043190278

ABSTRACT:
The invention concerns a process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolysing the enamino group in the resulting 7.beta.-acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.

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March, "Advanced Organic Chemistry," (1968), pp. 464-465, 482.

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