2-(Thi)oxo-3-imidazolyl-(2)-tetrahydroimidazoles

Details 2-(Thi)oxo-3-imidazolyl-(2)-tetrahydroimidazoles 2-(Thi)oxo-3-imidazolyl-(2)-tetrahydroimidazoles

1973-10-02

1976-12-21

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243B, 260243R, 260248R, 2602495, 2602471R, 2602475D, 2602477R, 260250AH, 260250RN, 2602564C, 2602565R, 260268H, 2602937, 260302H, C07D40314

Patent

active

039989526

ABSTRACT:
Imidazoles of the formula I ##STR1## wherein one of the radicals R.sub.1 and R.sub.2 denotes hydrogen or lower alkyl and the other denotes the nitro group, R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkyl-sulphonyl-lower alkyl or amino-lower alkyl, R.sub.4 is oxo or thioxo, R.sub.5 - if R.sub.1 is the nitro group - is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl, acyl, aryl or a heterocyclic radical or R.sub.5 -- if R.sub.2 is the nitro group -- is aryl or a heterocyclic radical, with the exception of an optionally substituted 2-imidazolyl group, and alk is lower alkylene and their therapeutically usable salts, S-oxides, sulphones or N-oxides are useful as agents against amoebae, schistosomes, filariae, trichomonades and bacteria and as intermediates.

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