Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin

Details Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin

1975-10-28

1976-12-21

Demers, Arthur P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260251Q, 260562B, C07C11900

Patent

active

039988830

ABSTRACT:
A novel process is described for the preparation of 6-chloro-2-chloromethyl-4-phenylquinazoline-3-oxide, a key intermediate in the synthesis of the known useful psychotherapeutic agents: chlorodiazepoxide and diazepam. This intermediate is prepared by the cyclization of 2-(1'-chloroimino-2'-chloromethyl)-5-chlorobenzophenone, itself a new compound. This compound in turn is prepared by the chloroacetylation of 2-amino-5-chlorobenzophenone to 2-chloroacetamido-5-chlorobenzophenone, another novel compound, and subsequent iminochloride formation.

REFERENCES:
patent: 3714188 (1973-10-01), Bell et al.
Reeder et al., Chem. Abstracts, 68 (1968), No. 69054.

Affiliated with

Also associated with

Rating

Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1838849