Substituted anilide esters of 16-substituted PGE.sub.2

Details Substituted anilide esters of 16-substituted PGE.sub.2 Substituted anilide esters of 16-substituted PGE.sub.2

1974-11-14

1976-12-21

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424305, C07C17700

Patent

active

039988694

ABSTRACT:
Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.

REFERENCES:
Fieser et al., Reagents for Organic Synthesis, pp. 86-1229, (1967).

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