Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-07
2000-05-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514256, 514307, 514311, 514357, 514365, 514381, 514394, 514400, 514406, 514419, 514427, 514461, 546333, A61K 3134, A61K 3138, A61K 314409, A61K 3147, C07D21356
Patent
active
06066634&
ABSTRACT:
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
REFERENCES:
Izzo et al., Medline Abstract No. 98349734, 1998.
Christensen et al., Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents, Annual Reports in Medicinal Chemistry, vol. 29, pp. 185-194, 1994.
Thompson et al., Assay of Cyclic Nucleotide Phosphodiesterase and Resolution of Multiple Molecular Forms of the Enzyme, Advances in Cyclic Nucleotide Research, vol. 10, pp. 69-92, 1979.
Brendel Klaus
Gross Paul
Pamukcu Rifat
Piazza Gary A.
Sperl Gerhard J.
Cell Pathways Inc.
Rao Deepak R.
Shah Mukund J.
Stevenson Robert W.
University of Arizona
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