3-aminopyrroles, methods for their synthesis and for their pharm

Details 3-aminopyrroles, methods for their synthesis and for their pharm 3-aminopyrroles, methods for their synthesis and for their pharm

1995-05-19

1997-11-04

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548518, 548532, 546208, 544141, C07D20734

Patent

active

056841604

ABSTRACT:
The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles.
Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents.
The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations.
Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.

REFERENCES:
patent: 4198502 (1980-04-01), Tarzia et al.
Knoll, et al.; Chimija Geterociklicheskih Soedinenijg (1985), No. 5, pp. 628-630 (Synthesis ester of substituted .beta.-aminopyrrole-2-carboxylic acids from thioacrylic acids and glycine ethers.
Tarzia, et al.; Farmaco, Ed. Sci. (1984), 39(6), pp. 538-558; Synthesis and pharmacological evalution of a series of analgesic and antiinflammatory 4-aminopyrroles.

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