Preparation of carboxyalkyl derivatives as inhibitors of matrix

Details Preparation of carboxyalkyl derivatives as inhibitors of matrix Preparation of carboxyalkyl derivatives as inhibitors of matrix

1996-09-19

1997-11-04

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544264, 544336, 544358, 546152, 546193, 546249, 548152, 548206, 548213, 548215, 548221, 5483351, 5483435, 548250, 548440, 548469, 548470, 548489, 548491, 548530, 549 6, 549 23, 549 30, 549 33, 549 49, 549229, 549266, 549273, 549307, 549313, 568735, C07C 39225, C07D20902, C07D20700, C07D26304, C07D27704, C07D30700, C07D41308, C07D27900

Patent

active

056841523

ABSTRACT:
Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. This invention relates to a process of making the carboxy-peptidyl compounds of formula I. ##STR1##

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