Methods for inhibiting cardiac fibroblast growth and cardiac fib

Details Methods for inhibiting cardiac fibroblast growth and cardiac fib Methods for inhibiting cardiac fibroblast growth and cardiac fib

1996-09-05

1997-11-04

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31495

Patent

active

056840071

ABSTRACT:
Methods are disclosed for inhibiting cardiac fibroblast growth, and for inhibiting cardiac fibrosis, wherein said methods use, as the active agent, a carbostyril derivative.

REFERENCES:
patent: 4415572 (1983-11-01), Tominaga et al.
Borer et al, "Regurgitant Valvular Diseases as a Cause of Heart Failure and Sudden Death: Cell Biology an Pathophysiology", J. of Heart Failure, 3(1):84 (Abstract 333) (May 1996).
Yoshinaka et al, "Alterations of the Cytoskeletal Organization in Tumor Cell Lines by a Cardiotonic Drug, Vesnarinone, through Protein Tyrosine Phosphorylation", Experimental Cell Research, 219:21-28 (1995).
Ross et al, "Low Dose, But Not High Dose, Vesnarinone Decreases Survival of Cardiac Fibroblasts Isolated from Normal and Aoric Regurgitant Hearts", J. of Investigative Medicine, 44(7):408A (Sep. 1996).

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