Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of

Details Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of

1991-03-28

1992-07-07

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548428, 544142, 544 60, 546200, 546272, C07D48704, A61K 3140

Patent

active

051283646

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4778812 (1988-10-01), Jirkovsky
patent: 4822809 (1989-04-01), Summers et al.
patent: 4822811 (1989-04-01), Summers
Leadbetter et al., J. Org. Chem. vol. 39, No. 24 (1974), pp. 3580-3583.

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