Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind

Details Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind

1990-06-08

1992-07-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548432, 548508, 548509, C07D491052, A61K 3140

Patent

active

051283638

ABSTRACT:
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are useful anti-inflammatory and analgesic agents.

REFERENCES:
patent: 4076831 (1978-02-01), Demerson et al.
patent: 4810699 (1989-03-01), Sabatucci et al.
patent: 4960902 (1990-10-01), Failli
W. A. Sheppard, J. Am. Chem. Soc., 85, 1314-1318 (1963).
P. N. Craig, J. Med. Chem., 14, 680-684 (1971).
W. A. Sheppard, J. Am. Chem. Soc., 83, 4860-4861 (1961).

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