Restriction fragment length polymorphism test for haplotyping do

Details Restriction fragment length polymorphism test for haplotyping do Restriction fragment length polymorphism test for haplotyping do

1992-04-07

1995-09-19

Fleisher, Mindy B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, C07H 2104, C12Q 168

Patent

active

054516706

ABSTRACT:
The major histocompatibility complex (MHC) of domesticated fowl, the B system, is known to contain three subregions which are identified as B-F, B-G and B-L. This invention includes a cDNA clone encoding a B-G antigen of the B system. MHC haplotyping is accomplished by use of novel probes provided by clones to detect restriction fragment length polymorphism (RFLP) patterns typical for various B-G subregion alleles.
Additional information concerning this invention is set forth in the attached manuscript entitled "Hypervariable sequence diversity in Ig V-like and leucine heptad domains in chicken histocompatibility B-G antigens".

REFERENCES:
Kaufman et al, Immunogenetics, vol. 30, 1989, pp. 440-451.
Miller et al, Proc. Natl. Acad. Sci. USA, vol. 88, 1991, pp. 4377-4381.

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