Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acid

Details Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acid Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acid

1985-04-22

1987-06-09

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514277, 514346, 514357, 514399, 544335, 546291, 546340, 546342, 548341, C07D23926, C07D21355, C07D207327, A61K 3144

Patent

active

046720669

ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Y is alkylene; Z is alkylene, ##STR2## the asterisk herein denotes bonding to the substituted acetophenone; R.sub.2 is hydrogen or lower alkoxy; and n is an integer of 1 to 3; A is ##STR3## and HET is a 5-or 6- membered nitrogen containing heterocyclic group, and their acid addition salts. The compounds of formula I of the invention are useful for the treatment of allergic conditions, such as, asthma and cardiovascular diseases, such as, angina and arrhythmias.

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