Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one c

Details Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one c Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one c

1985-11-21

1987-06-09

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540552, 544 91, 544364, 544371, 546269, 546277, 548363, 548364, 548367, 548369, 548218, A61K 31495, C07D40114, C07D40306

Patent

active

046720634

ABSTRACT:
5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds of the Formula ##STR1## in which R.sub.1 is a straight-chain, branched or cyclic alkyl group with up to 6 carbon atoms, Z is an alkylene chain with 2 to 4 carbon atoms, and 1-phenyl substituent is an optionally substituted phenyl ring, and R.sub.4 is a phenyl or pyridyl group which is optionally substituted and their preparation are described. The compounds have pharmacological, particularly antiallergic, properties.

REFERENCES:
patent: 3169966 (1965-02-01), Schmidt
patent: 3362956 (1968-01-01), Archer
patent: 4442102 (1984-04-01), Heinemann et al.
patent: 4515944 (1985-05-01), Heinemann et al.
patent: 4537975 (1985-08-01), Heinemann et al.
Jasserand et al., CA 105-153058m.
Chemical Abstracts Substance Index, vol. 98, p. 6053CS.
Chemical Abstracts, vol. 98, entry 72018h.
Houden-Weyl, "Methoden der Organischen Chemie", vol. XI/1, fourth edition, pp. 108-111.

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