Estradiol compositions and methods for topical application

Details Estradiol compositions and methods for topical application Estradiol compositions and methods for topical application

1991-07-17

1992-07-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424 65, 424447, 424448, 514944, 514946, 514947, 401213, A61F 1300

Patent

active

051281384

ABSTRACT:
A mixture of estradiol or other estrogen and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer provides a matrix which gradually releases the medicament upon application to the skin of a patient in the form of an ointment, gel or film. The polymer provides for the slow and sustained release of the medicament upon topical application to the skin so that the concentration of drug in the blood plasma of the patient is maintained within the levels required for clinical efficacy.

REFERENCES:
patent: 2776924 (1957-01-01), Martin
patent: 2904810 (1959-09-01), Dence
patent: 3214338 (1965-10-01), Ehrlich
patent: 3287222 (1966-11-01), Larde et al.
patent: 3608070 (1971-09-01), Nouvel
patent: 3803300 (1974-04-01), Pospischil
patent: 3948262 (1976-04-01), Zaffaroni
patent: 3972995, Tsuk et al.
patent: 4091091 (1978-05-01), Terrill
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4210633 (1980-07-01), Takruri et al.
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4383993 (1983-05-01), Hussain et al.
patent: 4436738 (1984-03-01), Bequette et al.
patent: 4482534 (1984-11-01), Blank
patent: 4533540 (1985-08-01), Blank
patent: 4687481 (1987-08-01), Nuwayser
patent: 4788062 (1988-11-01), Gale
L. Schenkel et al., "Transdermal Absorption of Estradiol From Body Sites Is Comparable", Journal of Controlled Release, 4, pp. 195-201 (1986).
K. A. Steingold et al., "Treatment Of Hot Flashes With Transdermal Estradiol Administration", J. Clin. Endocrin. Metab., 61, pp. 627-632 (1985).
V. A. Place et al., "A Double-Blind Comparative Study of Estraderm and Premarin in the Amelioration of Postmenopausal Symptoms", Amer. J. Obstet. Gynecol., 152, pp. 1092-1099 (1985).
M. S. Powers et al., "Pharmacokinetics and pharmacodynamics of Transdermal Dosage Forms of 17 Beta-Estradiol: Comparison With Conventional Oral Estrogens Used for Hormone Replacement", Amer. J. Obstet. Gynecol., 152, pp. 1099-1106 (1985).
D. E. Resetarits et al., "Dissolution Behavior of 17 Beta-Estradiol (E.sub.2) From Providone Coprecipitates: Comparison With Microcrystalline and Macrocrystalline E.sub.2 ", Intl. J. Pharm., 2, pp. 113-123 (1979).
R. E. Lacey et al., "Factors Affecting The Release Of Steroids From Silicones" in Controlled Release of Biologically Active Agents, Edited by A. C. Tanquary and R. E. Lacey, pp. 117-144 (Plenum Press 1974).
L. R. Laufer et al., "Estrogen Replacement Therapy By Transdermal Estradiol Administration", Amer. J. Obstet. Gynecol., 146, pp. 533-540 (1983).
M. L. Padwick et al., "Efficacy, Acceptability, And Metabolic Effects Of Transdermal Estradiol In The Management Of Postmenopausal Women", Amer. J. Obstet. Gynecol., 152, pp. 1085-1091 (1985).
W. R. Good et al., "A new Transdermal Delivery System For Estradiol", Journal of Controlled Release, 2, pp. 89-97 (1985).
R. H. Guy et al., "Transdermal Drug Delivery: A Perspective", Journal of Controlled Release, 4, pp. 237-251 (1987).
J. Holst et al.,. "A Comparison Of Liver Protein Induction In Postmenopausal Women During Oral and Percutaneous Oestrogen Replacement Therapy", Br. J. Obstet. Gynecol., 90, pp. 355-360 (1983).

Affiliated with

Also associated with

Rating

Estradiol compositions and methods for topical application does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Estradiol compositions and methods for topical application, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Estradiol compositions and methods for topical application will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1828430