Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde

Details Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde

1990-03-21

1992-02-18

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549398, C07D31158

Patent

active

050896377

ABSTRACT:
Optically active (C.sub.1 -C.sub.3) alkyl 2R-chroman-2-carboxylates are prepared by partial hydrolysis of the corresponding racemic ester using a microbial lipase as catalyst. Said 2R-chromancarboxylate is converted via novel 2R-(hydroxymethyl) chroman, 2R-(trifluoromethylsulfonyloxymethyl) chroman and 2R-benzylchroman intermediates into 2R-benzylchroman-6-carbaldehyde, a compound of known utility in the manufacture of certain hypoglycemic agents.

REFERENCES:
Chem. Abst., 109: 170,552t (1988).
Chem. Abst., 109: 92,718k (1988).
Chem. Abst. 108: 167,322s (1988).
Chem. Abst., 106: 67,298d (1987).
Chem. Abst., 103: 32,0762 (1985).
Chem. Abst., 97: 162,066f (1982).

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