4-phenylphthalazine derivatives which inhibit platelet aggregati

Details 4-phenylphthalazine derivatives which inhibit platelet aggregati 4-phenylphthalazine derivatives which inhibit platelet aggregati

1991-03-27

1992-02-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544237, A61K 3150, C07D23734, C07D40512, C07D40514

Patent

active

050894943

ABSTRACT:
4-Phenylphthalazine derivatives having platelet aggregation inhibitory activity of the formula: ##STR1## wherein R.sup.1 is an alkyl or hydroxyalkyl group of 1-5 carbon atoms; R.sup.2 is a hydrogen atom or an alkyl group of 1-5 carbon atoms; or R.sup.1 and R.sup.2, when taken together, may represent an alkylene group of 2-6 carbon atoms, said group optionally containing one or more oxygen atoms; R.sup.3 and R.sup.4 are independently a hydrogen or halogen atom, an alkyl or alkoxy group of 1-4 carbon atoms, or when two of R.sup.3 are adjacently positioned, (R.sup.3)l may represent a --O--(CH.sub.2).sub.p --O-- group and/or when two of R.sup.4 are adjacently positioned, (R.sup.4).sub.m may represent a --O--(CH.sub.2).sub.p --O-- group; R.sup.5 is a hydrogen or halogen atom, an alkyl or alkoxy group of 1-4 carbon atoms, a trifluoromethyl group or a hydroxy group, or when two of R.sup.5 are adjacently positioned, (R.sup.5).sub.n may represent a --O--(CH.sub.2).sub.p --O-- group; p is an integer of 1-3; l and m are independently an integer of 1-2; and n is an integer of 1-3, and optical isomers and pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
Patent Abstracts of Japan, vol. 5, No. 114 (C-64) (786) 23 Jul. 1981, of JP-A-56 53659 (Mitsubishi Yuki Yakuhin K.K.) 13 May 1981, [cat. D].
Patent Abstracts of Japan, vol. 5, No. 114 (-64) (786) 23 Jul. 1981, of JP-A-56 53660 (Mitsubishi Yuka Yakuhin K.K.) 13 May 1981, [cat. D].
Patent Abstracts of Japan, vol. 10, No. 112 (-342) (2169) 25 Apr. 1986, of JP-A-60 243074 (Mitsubishi Yuka Yakuhin K.K.) 03 December 1985, [cat. D].
Chemical Abstracts, vol. 71, (Aug. 1969) Columbus, Ohio, USA H. H. Holava, Jr., et al.: "1-Substituted 4-aryl-[or 4-aralkyl-]phthalazines", ref. No. 22093A.
Holava, J Med. Chem. 12, 555 (1969).

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