Substituted phenyl-amidines

Details Substituted phenyl-amidines Substituted phenyl-amidines

1977-01-25

1979-03-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

544242, 544315, 544318, 544330, 544332, 544335, 260308D, 260562N, 260564G, 548347, 548351, 548352, 548353, A61K 3116, C07C12300

Patent

active

041466470

ABSTRACT:
The present invention provides compounds of the formula: ##STR1## in which A is CH.sub.2, CHOH, CH.sub.2 O, CH.sub.2 S, CH.sub.2 NH, OCH.sub.2, SCH.sub.2, NH, NHCH.sub.2, NHCOCH.sub.2 or CH.sub.2 NHCH.sub.2, X.sub.1 is H, halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, X.sub.2 is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, Z is 2-pyrimidinyl or C(.dbd.NR.sub.1)NHR.sub.2 (where R.sub.1 is H and R.sub.2 is H, OH or CH.sub.2 CO.sub.2 Et, or R.sub.1 and R.sub.2 together form CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 or N.dbd.N), and their addition salts. The compounds of formula I and their salts are useful in therapy as hypotensive agents.

REFERENCES:
patent: 3115525 (1963-12-01), D'Alo
patent: 3234255 (1966-02-01), Hackmann et al.
patent: 3394181 (1968-07-01), Bell
patent: 3855249 (1974-12-01), Lafon

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