2-Decarboxy-2-alkylcarbonyl-PGA or PGB compounds

Details 2-Decarboxy-2-alkylcarbonyl-PGA or PGB compounds 2-Decarboxy-2-alkylcarbonyl-PGA or PGB compounds

1978-07-17

1979-03-27

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260590C, C07C17700

Patent

active

041465610

ABSTRACT:
The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).

REFERENCES:
patent: 3931296 (1976-01-01), Hayashi et al.
patent: 3953435 (1976-04-01), Hayashi et al.
patent: 4066751 (1978-01-01), Hayashi et al.
Derwent CPI Farmdoc 93049x/50 (JA-044211).
Derwent Farmdoc CPI No. 35953 x.
Derwent Farmdoc CPI No. 94924 x.

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