Process for the production of 7-acylindoles

Details Process for the production of 7-acylindoles Process for the production of 7-acylindoles

1994-07-26

1995-08-29

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548468, 548490, C07D40106

Patent

active

054461626

ABSTRACT:
A process for the production of 7-acylindoles of the general formula: ##STR1## starting from indoline of the formula: ##STR2## Indoline is cyanized in a first stage to 7-cyanoindoline of the formula: ##STR3## The latter is catalytically dehydrogenated in a second stage to 7-cyanindole of the formula: ##STR4## The latter is then acylated in a third stage with an organometallic compound of the formula:

REFERENCES:
patent: 4221716 (1980-09-01), Lo et al.
patent: 5120749 (1992-06-01), Summers et al.
CA 116:143891, Ward 1992.
CA 90:151918 Ivanova et al. 1979.
Oldroyd et al. J. Photochem. Photobiol. 1991. 57(1-3). 207-16. as CA abstract.
Walsh et al. J. Med. Chem. 1984. 27(11). 1379-88 as CA Abstract.
Kim et al. J. Heterocycl. Chem. 1981. 18(7). 1365-71 as CA abstract.

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