Process for preparing imidazopyridine derivatives

Details Process for preparing imidazopyridine derivatives Process for preparing imidazopyridine derivatives

1994-09-19

1995-08-29

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47102

Patent

active

054461596

ABSTRACT:
A process for preparing imidazopyridines of the general formula: ##STR1## wherein R.sub.1 is an alkyl, cycloalkyl, aryl or aralkyl group or is a heterocyclic radical, R.sub.2 and R.sub.4 are identical or different and are hydrogen, a hydroxy, a cyano, alkyl, cycloalkyl, aryl or aralkyl group or are an alkanoyl or an alkoxy-carbonyl group, and R.sub.3 is hydrogen, an alkyl, aryl or aralkyl group or a halogen atom. In the key step of the process, an amidine of the formula: ##STR2## is cyclized with a 1,3-dicarbonyl compound of the general formula: ##STR3## The imidazopyridines are valuable intermediates for the preparation of angiotensin II antagonists.

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Bader, H. et al., J. Chem. Soc., (1950), p. 2780.

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