Oligonucleotides containing 4'-substituted nucleotides

Details Oligonucleotides containing 4'-substituted nucleotides Oligonucleotides containing 4'-substituted nucleotides

1993-12-09

1995-08-29

Stone, Jacqueline M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 2432, 536 253, 536 2532, C07H 2100

Patent

active

054461375

ABSTRACT:
This invention relates to oligonucleotides having at least one nucleotide that is substituted at the 4' position of the sugar moiety with a substituent other than hydrogen. These oligonucleotides are useful in hybridization assays and as therapeutic agents.

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Azhayev, et al., Tetrahedron Letters, vol. 34:40 (1993), pp. 6435-6438 "Analogues of Oligonucleotides Containing 3'-Deoxy-.beta.-D-Psicothymidine".
Dan, et al., Bioorganic & Medicinal Chemistry Letters, vol. 3:4 (1993), pp. 615-618 "Nucleosides & Nucleotides, 118. Synthesis of Oligonucleotides Containing ANovel 2"-Deoxyuridine Analogue That Carries An Aminoalkyl Tether At 1'-Position; Stabilization Of Duplex Formation By an Intercalating Group Accommodated In The Minor Groove".
O-Yang, et al., Tetrahedron Letters, vol. 33:1 (1992), pp. 37-40, "Synthesis of 4'-Cyanothymidine and Analogs as Potent Inhibitors of HIV.sup.1 ".
Maag, et al., Journal of Medicinal Chemistry, vol. 35 (1992), pp. 1440-1451 "Synthesis and Anti-HIV Activity of 4'-Azido- and 4'-Methoxynucleosides".

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