Phenyl-lower-alkyl piperidines and pyrrolidines

Details Phenyl-lower-alkyl piperidines and pyrrolidines Phenyl-lower-alkyl piperidines and pyrrolidines

1981-08-10

1983-11-22

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546248, 260239B, 548569, 548571, 548574, C07D21106, C07D20704

Patent

active

044170521

ABSTRACT:
N-{2, 3- and 4-[R.sub.1 -(phenyl)-C(.dbd.X)]-phenyl-loweralkyl} amines, useful as anti-inflammatory agents, are prepared either by reduction of 2-, 3- or 4-[R.sub.1 -(phenyl)CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-loweralkylamine; by reaction of a 2-, 3- or 4-lithiophenyl-loweralkylamine with a R.sub.1 -(phenyl)-carboxaldehyde, a R.sub.1 -(phenyl)-lower-alkyl ketone or a R.sub.1 -(phenyl)-carbonitrile; by reaction of a 2-, 3- or 4-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkyl tosylate with an appropriate amine; or by transformations involving manipulations of a carbonyl or carbinol group.

REFERENCES:
patent: 3770748 (1973-11-01), Borck et al.
patent: 3772311 (1973-11-01), Prakash
patent: 3773772 (1973-11-01), Prakash
patent: 3773944 (1973-11-01), Lippmann
patent: 3801594 (1974-04-01), Poletto et al.
patent: 3803127 (1974-04-01), Williamson et al.
patent: 3810985 (1974-05-01), Diamond
patent: 4069256 (1978-01-01), Zenitz
patent: 4308382 (1981-12-01), Zenitz

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