Process for the preparation of 8.alpha.-substituted 6-methylergo

Details Process for the preparation of 8.alpha.-substituted 6-methylergo Process for the preparation of 8.alpha.-substituted 6-methylergo

1981-05-12

1983-11-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 68, 546 69, C07D51902

Patent

active

044170513

ABSTRACT:
A process for preparing an 8.alpha.-substituted 6-methyl-10.alpha.-H-ergoline of the formula ##STR1## wherein R.sub.1 is HN--CO--NX.sub.2 (wherein X is hydrogen, methyl or ethyl), CO--NH--NX.sub.2, CO--NX.sub.2, or CH.sub.2 OX, comprises reducing the corresponding 8.alpha.-substituted-9,10-didehydro-6-methylergoline, with an alkali metal or alkaline earth metal dissolved in a nitrogen compound which is a primary or secondary C.sub.1-3 -alkylamine, a hexa-C.sub.1-2 -alkyl-phosphoric triamide or ammonia at a temperature of -70.degree. to -30.degree. C.

REFERENCES:
patent: 3901893 (1975-08-01), Karacsony et al.
patent: 3968111 (1976-07-01), Bach et al.
patent: 4075212 (1978-02-01), Bach et al.
Medicinal Chemistry, Burger, 3rd Edition, Part II, Wiley Interscience (1970) p. 1514.
V. Zikan and M. Semonsky, Pharmazie, 23 (1968) pp. 147, 148.
A. Hoffman, Die Mutterkornalkaloide, Enke Verlag, Stuttgart 1964, pp. 38-50.

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