Alkenyl- and alkanylamines

Details Alkenyl- and alkanylamines Alkenyl- and alkanylamines

1972-01-28

1976-08-31

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029372, 2605011, 260562R, 260563R, 2605706, 260590C, 424267, 424316, 424330, C07C 8728, C07C 8729

Patent

active

039781291

ABSTRACT:
Novel alkenyl- and alkanylamines having the formula: ##EQU1## WHEREIN Am is lower-alkylamino, di-lower-alkylamino and piperidino; A is methylene and methylidyne; R is hydrogen, lower-alkyl, lower-alkoxy, halogen and trifluoromethyl; m is zero and one; n is one and two; X is halogen and the pharmaceutically acceptable acid addition salts thereof. The alkenylamines are prepared by contacting 1-cyclopropyl-1-phenyl-.omega.-amino-1-alkanols with strong mineral acids. The alkanylamines are prepared by hydrogenation of the alkenylamines. Some of the compounds exhibit potent antagonism to the depressant effects of tetrabenazine.

REFERENCES:
patent: 3573304 (1971-03-01), Eberle et al.
varanyan et al. "Chemical Abstracts, vol. 70, pp. 291, Abstract 96277Q (1969).
Hoffsommer et al., "Journal of Organic Chemistry", vol. 27, pp. 4134-4137 (1962).

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