2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, and derivative

Details 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, and derivative 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, and derivative

1976-04-08

1977-09-27

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260590FB, 260511, C07C 4976, A01N 924

Patent

active

040512606

ABSTRACT:
2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where one of R.sup.2 and R.sup.3 is hydrogen, and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene; and R' and R.sup.4 are alkoxy, or together R' and R.sup.4 are .dbd.O, .dbd.NOH, .dbd.NNHCONH.sub.2, or alkylenedioxy of the formula --O--CH.sub.2 --(CR.sup.5.sub.2).sub.n --CH.sub.2 --O-- where n.sub.5 is O-2, R.sup.5 is hydrogen or methyl when n is 1, and R.sup.5 is hydrogen when n is 2, or one of R' and R.sup.4 is --OH and the other is (SO.sub.3 Y) where Y is sodium or potassium. The compounds have anti-inflammatory, analgesic and anti-pyretic activities and, accordingly, are useful in the treatment of inflammation, pain and pyrexia.

REFERENCES:
patent: 3372196 (1968-03-01), Engelhardt
patent: 3478048 (1969-11-01), Edenhofer et al.
patent: 3551498 (1970-12-01), Tristram et al.
patent: 3697581 (1972-10-01), Humber
patent: 3833655 (1974-09-01), Edenhofer et al.
patent: 3836585 (1974-09-01), Tristram et al.
patent: 3883593 (1975-05-01), Beregin et al.

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