Process for producing cephalosporins

Details Process for producing cephalosporins Process for producing cephalosporins

1974-11-29

1976-08-31

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50102

Patent

active

039780538

ABSTRACT:
A process for producing a compound of the formula (I) ##SPC1##
wherein R.sub.2 is a hydrogen atom or an ester protective group, which is useful as a precursor for the production of cephalosporin derivatives, comprising reacting a phosphoramide derivative of cephalosporin of the formula (II) ##SPC2##
wherein R.sub.1 is a lower alkyl group and R.sub.2 is as defined above, with a phosphorus acid. A further embodiment includes preparing the phosphoramide derivative of cephalosporin of the formula (II) by reactng a compound of the formula (III) ##SPC3##
wherein R.sub.1 and R.sub.2 are as defined above, with an acid compound.

REFERENCES:
patent: 3725397 (1973-04-01), Graham et al.
patent: 3725399 (1973-04-01), Ellerton et al.
patent: 3843637 (1974-10-01), Rubinfeld et al.
patent: 3852281 (1974-12-01), Verweij

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