Di(alkylamino) derivatives of chloronitropyrazines useful as adj

Details Di(alkylamino) derivatives of chloronitropyrazines useful as adj Di(alkylamino) derivatives of chloronitropyrazines useful as adj

1982-07-19

1983-11-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544407, 544409, C07D24116, A61K 31495

Patent

active

044168829

ABSTRACT:
Di(alkylamino) derivatives of chloronitropyrazines are prepared from dichloronitropyrazinamine by diazotization of the amine followed by halogen exchange to produce an intermediate dichloro-halo nitropyrazine followed by reaction with one or two moles of an alkyl amine to effect replacement of one or two of the pyrazine halogens.

REFERENCES:
patent: 2944061 (1960-06-01), Jacob et al.
patent: 3660397 (1972-05-01), Jones et al.
patent: 3772313 (1973-11-01), Gizycki et al.
Ainsworth, P. S. et al., Canadian J. of Biochemistry vol. 56 (1978), pp. 457-461.
Adams, G. E. et al., The Lancet, Jan. 1976, pp. 186-188.
Cheeseman et al., Advances in Heterocyclic Chem. vol. 14, Achademic Press, New York (1973), pp. 156, 157, 163.
Olive, Peggy, Cancer Research, vol 39 (1979), pp. 4512-4515.

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