Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazep

Details Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazep Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazep

1989-11-24

1993-06-01

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C07D49822, C07D40304, C07D40104, A61K 31555

Patent

active

052159841

ABSTRACT:
This invention relates to spiro-](piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.

REFERENCES:
patent: 4268515 (1981-05-01), Efflund
patent: 4321385 (1982-03-01), Efflund
patent: 4329464 (1982-05-01), Efflund
patent: 4812450 (1989-03-01), Efflund
Davis et al. J. Med. Chem. 26, 1505 (1983).

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