Process for the production of .alpha.-[2-(p-chlorophenoxy)-isobu

Details Process for the production of .alpha.-[2-(p-chlorophenoxy)-isobu Process for the production of .alpha.-[2-(p-chlorophenoxy)-isobu

1976-12-15

1977-09-27

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424266, C07D21355

Patent

active

040511430

ABSTRACT:
The application discloses a novel improved process for the production of .alpha.-[2-(p-chlorophenoxy)-isobutyl]-.beta.-nicotinoyl glycol ester, a known compound having a lipid-lowering effect, by the reaction of .alpha.-[2-chlorophenoxy)-isobutyryl]-.beta.-ethyl chloride ester with an alkali salt of nicotinic acid, preferably sodium nicotinate, preferably in a high-boiling polar or dipolar aprotic solvent, especially dimethylformamide, most preferably at a temperature of about 120.degree. - 180.degree. C., and most advantageously in refluxing dimethylformamide. An unpredictable increase in yields of the desired product over yields attainable by previously-available processes is thereby obtained.

REFERENCES:
patent: 3723446 (1973-03-01), Scherm et al.
Scherm et al., Chem. Abstracts, vol. 78(25), i59451e, June 25, 1973.

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