2-[(Substituted-piperidinyl or tetrahydropyridinyl)alkyl]-1H-ben

Details 2-[(Substituted-piperidinyl or tetrahydropyridinyl)alkyl]-1H-ben 2-[(Substituted-piperidinyl or tetrahydropyridinyl)alkyl]-1H-ben

1974-08-28

1976-01-27

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260281N, 260281NH, 26029378, 26029372, 26029384, 424258, C07D40106

Patent

active

039352277

ABSTRACT:
Compounds of the following formula and their acid addition salts ##SPC1##
Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is selected from ##SPC2##
Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as anti-inflammatory agents.

REFERENCES:
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patent: 3330834 (1967-07-01), Senshu
patent: 3697525 (1972-10-01), Okada
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Physicians Desk Reference, pp. 951, 1477, (1974).
Merck Index, 8th Edition, p. 735.
Webb et al., Chem. Abs. 76, 59284t (1972).
Vernon et al., Chem. Abs. 64, 2029e (1966).
Wills et al., Chem. Abs. 75, 87712d (1971).
Daewonski et al., Chem. Abs. 21, 2682-2683, (1927).

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