Carboxyalkyl dipeptides and medical use thereof in treating hype

Details Carboxyalkyl dipeptides and medical use thereof in treating hype Carboxyalkyl dipeptides and medical use thereof in treating hype

1987-11-04

1989-04-04

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514412, 548492, 548533, A61K 3140, C07D20926

Patent

active

048187496

ABSTRACT:
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure.
The compounds of the present invention are compounds of the formulae ##STR1## and the pharmaceutically acceptable salts thereof, wherein R and R.sup.6 are the same or different and are hydroxy or lower alkoxy;

REFERENCES:
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4508729 (1985-04-01), Vincent et al.

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