Method of binding two or more DNA double helices and products fo

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 231, 536 243, 435 6, C07H 2100, C07H 2102, C07H 2104, C12Q 168

Patent

active

059488972

ABSTRACT:
This invention relates to a nucleic acid complex having double-stranded sections with a domain of guanine nucleotides. The domain comprises of a pair of substantially uninterrupted guanine sequences which bond together. This domain can interact with other similar domains such that two nucleic acid complexes with these domains have the ability to bind together to form DNA superstructures. The present invention also relates to a method of forming a nucleic acid superstructure using the engineered nucleic acid complexes.

REFERENCES:
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 5674683 (1997-10-01), Kool
Sen et al., Nature 344 :410-414 (1990).
Sen et al., Nature 334 :364-366 (1988).
Sen et al., Methods in Enzymology 211 :191-199 (1992).
Amato, I. "Designer Solids: Haute Couture in Chemistry" Science vol. 260, May 7, 1993: pp. 753-755.
Chen, J.H. E Seeman, N.C. "Synthesis from DNA of a Molecule With the Connectivity of a Cube" Nature vol. 350, Apr. 18, 1991: pp. 631-633.
Duckett, D.R. et al. "The Structure of the Holliday Junction, and Its Resolution" Cell vol. 55, Oct. 7, 1988: pp. 79-89.
Duckett, D.R. E Lilley, D.M.J. "The three-way DNA junction is a Y-shaped molecule in which there is no helix-helix stacking" EMBO Journal vol. 9, 1990: pp. 1659-1664.
Lu, M. et al. "Structure and Stability of Sodium and Potassium Complexes of dT.sub.4 G.sub.4 and dT.sub.4 G.sub.4 T" Biochemistry vol. 31, 1992: pp. 2455-2459.
Marsh, T.C. & Henderson, E. "G-Wires: Self-Assembly of a Telomeric Oligonucleotide, d(GGGGTTGGGG), into Large Superstructures" Biochemistry vol. 33, 1994: pp. 10718-10724.
Murphy, C.J. et al. "Long-Range Photoinduced Electron Transfer Through a DNA Helix" Science vol. 262, Nov. 12, 1993: pp. 1025-1029.
Seeman, N.C. et al. "DNA Nanoconstructions" Journal Vacuum Science and Technology vol. 12, Jul./Aug., 1994: pp. 1895-1903.
Sen, D. & Gilbert, W. "The Structure of Telomeric DNA: DNA Quadriplex Formation" Current Opinion in Structural Biology I, 1991: pp. 435-438.
Sen, D. & Gilbert W. "Novel DNA Superstructures Formed By Telomere-like Oligomers" Biochemistry vol. 31, No. 1, 1992: pp. 65-70.
Venczel, E.A. & Sen, D. "Parallel and Antiparallel G-DNA Structures from a Complex Telomeric Sequence" Biochemistry vol. 32, No. 24, 1993: pp. 6220-6228.
Wang, Y. et al. "Assembly and Characterization of Five-Arm and Six-Arm DNA Branched Junctions" Biochemistry vol. 30, N. 23, 1991: pp. 5667-5674.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of binding two or more DNA double helices and products fo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of binding two or more DNA double helices and products fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of binding two or more DNA double helices and products fo will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1805509

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.